TT 209. Objectives of the proyecto dos cero nueve and the Name of the Tomb Owner

El estudio y la conservación de la TT 209 son los objetivos básicos de la Misión Arqueológica de la Universidad de La Laguna en Luxor. Ésta es el núcleo en torno al cual se articula el Proyecto dos cero nueve, nombre con que denominamos al conjunto de actividades de los miembros de la Misión acerca del yacimiento mismo así como de la arquitectura funeraria, el ritual de enterramiento y sus liturgias durante la Dinastía XXV. El artículo presenta las razones que condujeron a centrar las actuaciones arqueológicas del grupo en esta tumba y los descubrimientos más importantes hasta este momento, de los que uno muy significativo es el nombre propio del propietario (Nisemro o Ashemro, Djuemro o quizás, incluso, Yiemro). Nombre y títulos además del estilo de los relieves permiten deducir la adscripción étnica del difunto –nubio– y la cronología del monumento.The study and conservation of TT 209 is the basic objective of the Archaeological Mission of the University of La Laguna in Luxor. This is the core around which the Proyecto dos cero nueve (Project two zero nine) is organised. The name encompasses the activities carried out by its members within the site itself and the architecture, burial ritual and funerary liturgies during the Twenty-fifth Dynasty. This paper deals with the reasons that led the team to focus its archaeological activities in this site and the most important discoveries so far, one of which is the name of the tomb owner (Nisemro or Ashemro, Djuemro or even Yiemro). Name and titles, in addition to the style of the reliefs, suggest that it was prepared for man of Nubian provenance. Additionally, this provides a new dating for the monument

Realeza y concepción del universo en los textos de las pirámides en Castilla a final de la Edad Media : tradición e influencia islámica

Tesis de la Universidad Complutense de Madrid, Facultad de Geografía e Historia, Departamento de Historia Antigua, leída el 05-02-1999Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaTRUEpu

La enfermedad tromboembólica venosa en urgencias hospitalarias; una aproximación a la práctica clínica diaria.

La enfermedad tromboembólica venosa (ETEV) engloba la trombosis venosa profunda (TVP) y el Tromboembolismo pulmonar (TEP). El TEP agudo es la forma más grave de presentación de la ETEV. Es la tercera enfermedad cardiovascular más frecuente (después del síndrome coronario agudo y el ictus), con una incidencia anual global de 100-200 casos /100.000 habitantes. La ETEV es una consecuencia de la interacción de riesgos establecidos y relacionados con el paciente y se basa en la formación de un trombo que acaba obstruyendo la circulación venosa como resultado de un desequilibrio entre los factores pro y anticoagulantes. En el 90% de los casos la sospecha de TEP viene dada por síntomas inespecíficos cómo: Disnea, dolor torácico y síncope (de manera aislada o combinados). En la literatura hay descritas varias escalas de probabilidad pre-test, las dos más validadas y utilizadas en los servicios de urgencias hospitalarias son: Wells y Ginebra. Además de estas escalas preclínicas contamos con el Dímero-D, que es la prueba de laboratorio más sensible en esta patología. Sus resultados se combinan con la probabilidad pre-test para descartar la patología en un gran número de pacientes, evitando al paciente el someterse a pruebas de imagen y evitando al sistema el gasto innecesario. La prueba Gold-Standard es el Angio-TC para el TEP y la Ecografía de extremidades inferiores para la TVP. El tratamiento tiene como objetivo la estabilización médica del paciente y el alivio de los síntomas, la resolución de la obstrucción vascular y la prevención de recurrencias. La prioridad a la hora de conseguir estos objetivos dependerá de la gravedad/pronóstico del paciente, dicho pronóstico es valorado por la escala de PESI. En la mayoría de las ocasiones, todos los objetivos se alcanzan con el tratamiento anticoagulante convencional

Magnetic reduced graphene oxide/nickel/platinum nanoparticles micromotors for mycotoxin analysis

Magnetic reduced graphene oxide/nickel/platinum nanoparticles (rGO/Ni/PtNPs) micromotors for mycotoxin analysis in food samples were developed for food-safety diagnosis. While the utilization of self-propelled micromotors in bioassays has led to a fundamentally new approach, mainly due to the greatly enhanced target?receptor contacts owing to their continuous movement around the sample and the associated mixing effect, herein the magnetic properties of rGO/Ni/PtNPs micromotors for mycotoxin analysis are additionally explored. The micromotor-based strategy for targeted mycotoxin biosensing focused on the accurate control of micromotor-based operations: 1) on-the-move capture of free aptamers by exploiting the adsorption (outer rGO layer) and catalytic (inner PtNPs layer) properties and 2) micromotor stopped flow in just 2 min by exploiting the magnetic properties (intermediate Ni layer). This strategy allowed fumonisin B1 determination with high sensitivity (limit of detection: 0.70 ngmL@1) and excellent accuracy (error: 0.05% in certified reference material and quantitative recoveries of 104:4% in beer) even in the presence of concurrent ochratoxin A (105?108:8% in wines). These results confirm the developed approach as an innovative and reliable analytical tool for food-safety monitoring, and confirm the role of micromotors as a new paradigm in analytical chemistry.Ministerio de Economía y CompetitividadComunidad de Madri

Toward early diagnosis of late-onset sepsis in preterm neonates: Dual magnetoimmunosensor for simultaneous procalcitonin and C-reactive protein determination in diagnosed clinical samples

Early diagnosis of sepsis, combining blood cultures and inflammation biomarkers, continues to be a challenge, especially in very low birth weight (VLBW) infants because of limited availability of blood samples. Traditional diagnostic procedures are cumbersome, not fast enough, and require relatively large volumes of sample. Empiric use of antibiotics, before diagnostic confirmation, is required to decrease mortality, leading to potential antibiotic resistance and side effects in VLBW infants. To solve such a serious problem, a dual magnetoimmunosensor is proposed for simultaneous assessment of two of the most important sepsis biomarkers: procalcitonin (PCT for early phase) and Creactive protein (CRP for late phase). This ?sample-to-result? approach exhibited excellent sensitivity, selectivity, precision, and stability using low sample volumes (<30 ?L) and under 20 min of total assay. The analytical usefulness of the approach was demonstrated by analyzing clinically relevant samples of preterm neonates with suspicion of sepsis.Ministerio de Economía y CompetitividadComunidad Autónoma de MadridFundación “La Caixa

Prussian Blue/Chitosan Micromotors with Intrinsic Enzyme-like Activity for (bio)-Sensing Assays

Prussian Blue (PB)/chitosan enzyme mimetic tubular micromotors are used here for on-the-fly (bio)-sensing assays. The micromotors are easily prepared by direct deposition of chitosan into the pores of a membrane template and in situ PB synthesis during hydrogel deposition. Under judicious pH control, PB micromotors display enzyme mimetic capabilities with three key functions on board: the autonomous oxygen bubble propulsion (with PB acting as a catalase mimic for hydrogen peroxide decomposition), 3,3',5,5'-tetramethylbenzidine (TMB) oxidation (with PB acting as a peroxidase mimic for analyte detection), and as a magnetic material (to simplify the (bio)-sensing steps). In connection with chitosan capabilities, these unique enzyme mimetic micromotors are further functionalized with acetylthiocholinesterase enzyme (ATChE) to be explored in fast inhibition assays (20 min) for the colorimetric determination of the nerve agent neostigmine, with excellent analytical performance in terms of quantification limit (0.30 mu M) and concentration linear range (up to 500 mu M), without compromising efficient micromotor propulsion. The new concept illustrated holds considerable potential for a myriad of (bio)-sensing applications, including forensics, where this conceptual approach remains to be explored. Micromotor-based tests to be used in crime scenes are also envisioned due to the reliable neostigmine determination in unpretreated samples.Ministerio de Economía, Industria y CompetitividadComunidad de MadridEuropean Commissio

Polymer-based micromotors fluorescence immunoassay for on the move sensitive procalcitonin determination in very low birth weight infants' plasma

A new fluorescence micromotor-based immunoassay (FMIm) has been developed forvprocalcitonin (PCT) determination as an early sepsis diagnostic analytical tool. The micromotorsvcombine the high binding capacity of the specific antibodies onto their polymeric polypyrrole outervlayer (PPy layer), with their magnetic guidance (Ni layer) and self-propulsion by catalytic generationvof oxygen bubbles (PtNP inner layer) to actively recognize the PCT antigen. This FMIm allowed avsensitive (LOD = 0.07 ng mL?1) and direct PCT determination in clinical samples from very lowbirth-vweight infants (VLBWI) with sepsis suspicion, using small volumes of sample (25 ?L) in a clinically relevant range of concentrations (0.5?150 ng mL?1). The good agreement between PCTvlevels obtained by our micromotor-based method and routine immunofluorescence hospitalvdetermination demonstrates the feasibility for the analysis in VLBWI samples and its potential as avpoint-of-care diagnostic tool for sepsis.Ministerio de Economía, Industria y Competitividad); Comunidad de Madrid; La Caix